Anti-Osmr Antibody Picoband®, Cy3 Conjugate

• Background:

  Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. Mosley et al. (1996) used degenerate PCR to clone a novel hematopoietin receptor which they called the oncostatin M-specific receptor beta subunit (OSMR-beta). Sequencing revealed that this gene encodes a 979-amino acid protein containing characteristic motifs of the hematopoietin receptor family.

• Description:

  Boster Bio Anti-Osmr Antibody Picoband® catalog # A07424-3. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody

• Gene Name:

  Serine/threonine-protein kinase AtPK1/AtPK6

• Gene ID:

  18414

• UniProt:

  O70458

• Host:

  Rabbit

• Reactivity:

  Mouse,Rat

• Cross Reactivity:

  No cross reactivity with other proteins.

• Immunogen:

  E.coli-derived mouse Osmr recombinant protein (Position: E673-Q968). Mouse Osmr shares 57.7% and 86.9% amino acid (aa) sequence identity with human and rat Osmr, respectively.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in all tissues.

• Applications:

  ELISA,WB,Flow Cytometry

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Function:

  Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

• Components:

  Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

• References & Citations:

  1. Arita, K., South, A. P., Hans-Filho, G., Sakuma, T. H., Lai-Cheong, J., Clements, S., Odashiro, M., Odashiro, D. N., Hans-Neto, G., Hans, N. R., Holder, M. V., Bhogal, B. S., Hartshorne, S. T., Akiyama, M., Shimizu, H., McGrath, J. A. Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. Am. J. Hum. Genet. 82: 73-80, 2008. 2. Dillon, S. R., Sprecher, C., Hammond, A., Bilsborough, J., Rosenfeld-Franklin, M., Presnell, S. R., Haugen, H. S., Maurer, M., Harder, B., Johnston, J., Bort, S., Mudri, S., and 18 others. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nature Immun. 5: 752-760, 2004. Note: Erratum: Nature Immun. 6: 114 only, 2005. 3. Jahani-Asl, A., Yin, H., Soleimani, V. D., Haque, T., Luchman, H. A., Chang, N. C., Sincennes, M.-C., Puram, S. V., Scott, A. M., Lorimer, I. A. J., Perkins, T. J., Ligon, K. L., Weiss, S., Rudnicki, M. A., Bonni, A. Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Nature Neurosci. 19: 798-806, 2016.

• Storage Conditions:

  At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

• Calculated Molecular Weight:

  52588 MW

• Observed Molecular Weight:

  110,180 kDa

• Fragment:

  IgG

• Applications Notes:

  Western blot, 0.25-0.5 μg/ml, Mouse, Rat
  Flow Cytometry (Fixed), 1-3 μg /1x10⁶ cells, Mouse
  ELISA, 0.1-0.5 μg/ml, -
  

• Subcellular Location:

  Cytoplasm. Nucleus.

• Protein Name:

  Serine/threonine-protein kinase AtPK1/AtPK6