Anti-Islet-1 ISL1 Monoclonal Antibody

• Description:

  Boster Bio Anti-Islet-1 ISL1 Monoclonal Antibody catalog # M02969-2. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human.

• Synonyms:

  Insulin gene enhancer protein ISL-1; Islet-1; ISL1;

• Gene Name:

  ISL1

• UniProt:

  P61371

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Purified recombinant fragment of human Islet-1 expressed in E. Coli.

• Clonality:

  Monoclonal

• Clone:

  Clone: 1H9

• Tissue Specificity:

  Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.

• Applications:

  WB, IHC, IF, ELISA

• Purification:

  Affinity purification

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity) .

• Molecular Weight:

  39036 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Insulin gene enhancer protein ISL-1

• Subcellular Location:

  Nucleus

• Protein Name:

  Insulin gene enhancer protein ISL-1