Anti-Dectin-2 CLEC6A Antibody

• Description:

  Boster Bio Anti-Dectin-2 CLEC6A Antibody catalog # A11863-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.

• Synonyms:

  C-type lectin domain family 6 member A ; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2

• Gene Name:

  CLEC6A

• UniProt:

  Q6EIG7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Synthesized peptide derived from the Internal region of human Dectin-2.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.

• Applications:

  WB, IHC, ELISA

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Binds high-mannose carbohydrates in a Ca (2+) -dependent manner (PubMed:28652405) . Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity) .

• Molecular Weight:

  23998 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  C-type lectin domain family 6 member A

• Subcellular Location:

  Membrane ; Single-pass type II membrane protein .

• Protein Name:

  C-type lectin domain family 6 member A