Anti-Protein NOV homolog Nov Antibody

• Description:

  Boster Bio Anti-Protein NOV homolog Nov Antibody catalog # A06319-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Protein NOV homolog; NovH; CCN family member 3; Insulin-like growth factor-binding protein 9; IBP-9; IGF-binding protein 9; IGFBP-9; Nephroblastoma-overexpressed gene protein homolog; NOV; CCN3, IGFBP9, NOVH;

• Gene Name:

  NOV

• UniProt:

  P48745

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from the Internal region of human NOV. AA range:221-270

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in endiothelial cells (at protein level) (PubMed:21063504) . Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.

• Applications:

  WB, IHC, ELISA

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162) . Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078) . Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287) . Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162) . Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355) . Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522) . Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078) . Involved in bone regeneration as a negative regulator (By similarity) . Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891) . Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity) . Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti- inflammatory effects occur secondary to the inhibition of NF- kappaB signaling pathway (PubMed:21063504) . Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity) . Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891) .

• Molecular Weight:

  39162 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Protein NOV homolog

• Subcellular Location:

  Secreted. Cytoplasm

• Protein Name:

  Protein NOV homolog