Anti-SIRP-alpha Antibody

• Description:

  Boster Bio Anti-SIRP-alpha Antibody catalog # A05151-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD172a; SIRPA; BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP;

• Gene Name:

  SIRPA

• UniProt:

  P78324

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human Sirp alpha1. AA range:451-500

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

• Applications:

  WB, IHC, ELISA

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity) . Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

• Molecular Weight:

  54967 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Tyrosine-protein phosphatase non-receptor type substrate 1

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Protein Name:

  Tyrosine-protein phosphatase non-receptor type substrate 1