Anti-TRPC3 Antibody

• Background:

  The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.

• Description:

  Boster Bio Anti-TRPC3 Antibody (Catalog # A01472-3) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  TRP3, TRP3, Short transient receptor potential channel 3, Transient receptor protein 3, TrpC3

• Gene Name:

  TRPC3

• UniProt:

  Q13507

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  TRPC3 antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect the three largest isoforms. TRPC3 antibody is predicted to not cross-react with TRPC6.

• Immunogen:

  TRPC3 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TRPC3. The immunogen is located within amino acids 710 - 760 of TRPC3.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

• Applications:

  ELISA, WB, IHC-P

• Field of Research:

  Signal Transduction, Neuroscience

• Purification:

  TRPC3 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.

• Molecular Weight:

  96009 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  TRPC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

• Fragment:

  IgG

• Other Gene Names:

  Transient receptor potential cation channel, subfamily C, member 3

• Subcellular Location:

  Membrane; Multi-pass membrane protein.

• Protein Name:

  Transient receptor potential cation channel, subfamily C, member 3