Anti-Corticoliberin CRH Antibody

• Background:

  Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1) . In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2) . Marked reduction in this protein has been observed in association with Alzheimer disease (3) .

• Description:

  Boster Bio Anti-Corticoliberin CRH Antibody (Catalog # A00629-2) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

• Synonyms:

  CRF, Corticoliberin, Corticotropin-releasing factor, CRF

• Gene Name:

  CRH

• UniProt:

  P06850

• Host:

  Rabbit

• Reactivity:

  Human

• Cross Reactivity:

  CRH antibody is human specific.

• Immunogen:

  CRH antibody was raised against a 16 amino acid peptide near the amino terminus of human CRH. The immunogen is located within amino acids 30 - 80 of CRH.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Produced by the hypothalamus and placenta.

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Homeostasis, Neuroscience

• Purification:

  CRH antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Hormone regulating the release of corticotropin from pituitary gland (By similarity) . Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity) .

• Molecular Weight:

  21422 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  CRH antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

• Fragment:

  IgG

• Other Gene Names:

  Corticotropin releasing hormone

• Subcellular Location:

  Secreted

• Protein Name:

  Corticotropin releasing hormone