Anti-SLAMF3 LY9 Antibody

• Background:

  The signaling lymphocyte-activation molecule family member 3 (SLAMF3), also known as LY9, is a cell surface receptor that is expressed on T and B lymphocytes and belongs to the CD150/SLAMF1 receptor family. SLAMF3 was identified through a yeast two-hybrid screening in which SLAMF3 bound to the X-linked lymphoproliferative disease gene product SAP, suggesting that in activated T cells, SLAMF3 signaling can be triggered SAP. Its expression on the cell surface appears to be regulated via its interaction with the clathrin-associated adaptor complex 2 (AP-2) . Despite its similarity to SLAMF1 in structure and interactions with SAP, SLAMF3-deficient mice do not exhibit phenotypic characteristics associated with SLAMF1- and SAP-deficient mice, suggesting that SLAMF3 plays other roles in T cell activation.

• Description:

  Boster Bio Anti-SLAMF3 LY9 Antibody (Catalog # A05830-2) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Hly9, mLY9, CD229, SLAMF3, T-lymphocyte surface antigen Ly-9, Cell surface molecule Ly-9

• Gene Name:

  LY9

• UniProt:

  Q9HBG7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  At least three isoforms of SLAMF3 are known to exist. SLAMF3 antibody is predicted to not cross-react with other SLAM protein family members.

• Immunogen:

  SLAMF3 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SLAMF3. The immunogen is located within amino acids 520 - 570 of SLAMF3.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients.

• Applications:

  ELISA, WB, ICC, IF

• Field of Research:

  Immunology

• Purification:

  SLAMF3 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727) . Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874) . May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4 (+) T-cells. May negatively regulate the size of thymic innate CD8 (+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity) .

• Molecular Weight:

  72139 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  SLAMF3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Lymphocyte antigen 9

• Subcellular Location:

  Membrane; Single-pass type I membrane protein. Cell membrane .

• Protein Name:

  Lymphocyte antigen 9