Anti-Thymic stromal lymphopoietin TSLP Antibody

• Background:

  Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. At least two differentially spliced isoforms of TSLP are known to exist.

• Description:

  Boster Bio Anti-Thymic stromal lymphopoietin TSLP Antibody (Catalog # A01096-2) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human.

• Synonyms:

  Thymic stromal lymphopoietin

• Gene Name:

  TSLP

• UniProt:

  Q969D9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Anti-TSLP antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TSLP. The immunogen is located within the last 50 amino acids of TSLP.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.

• Applications:

  ELISA, WB, IHC-P

• Field of Research:

  Immunology

• Purification:

  TSLP Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Isoform 1: Cytokine that induces the release of T-cell- attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c (+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

• Molecular Weight:

  18141 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  TSLP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Thymic stromal lymphopoietin

• Subcellular Location:

  Secreted

• Protein Name:

  Thymic stromal lymphopoietin