Anti-GTP-binding protein Rheb Rheb Antibody

• Background:

  Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.

• Description:

  Boster Bio Anti-GTP-binding protein Rheb Rheb Antibody (Catalog # A00827-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  RHEB2, RHEB2, GTP-binding protein Rheb, Ras homolog enriched in brain

• Gene Name:

  RHEB

• UniProt:

  Q15382

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Rheb antibody was raised against a 15 amino acid synthetic peptide from the middle region of human Rheb. The immunogen is located within amino acids 40 - 90 of Rheb.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitous. Highest levels observed in skeletal and cardiac muscle.

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Signal Transduction, Cancer

• Purification:

  Rheb Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.

• Molecular Weight:

  20497 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Rheb antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Ras homolog enriched in brain

• Subcellular Location:

  Endomembrane system

• Prediction Reactivity:

  Bovine

• Protein Name:

  Ras homolog enriched in brain