Recombinant Cynomolgus CD40/TNFRSF5/CD40L Receptor Protein (Fc Tag)

• Background:

  CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction.

• Abbreviation:

  CD40; TNFRSF5

• Synonyms:

  B-Cell Surface Antigen CD40; Bp50; CD40; CD40L Receptor; CDw40; TNFRSF5; Tumor Necrosis Factor Receptor Superfamily member 5

• UniProt:

  A0A2K5V585

• Accession Number:

  XP_005569275.1

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  Glu21-Arg193

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  46.3 kDa

• Observed Molecular Weight:

  48-70 kDa

• Species:

  Cynomolgus macaques