Recombinant Mouse S100A11 Protein (His Tag)

• Background:

  Protein S100-A11 (S100A11) is a member of the S-100 family. S100A11 is widely expressed in multi pletissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca (2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferatin of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel diagnostic marker in breast carcinoma.

• Abbreviation:

  S100A11

• Synonyms:

  Calgizzarin; EMAP; EMAPI; Emap1; Endothelial monocyte-activating polypeptide; Protein S100-A11; Protein S100-C; S100 calcium-binding protein A11; S100A11; S100a11; S100a14; S100c; cal

• UniProt:

  P50543

• Accession Number:

  P50543

• Expression System:

  E.coli

• Tag:

  N-His

• Sequence:

  Met1-Ile98

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  12.6 kDa

• Observed Molecular Weight:

  12 kDa

• Species:

  Mouse