Recombinant Mouse S100A8/CAGA Protein (His Tag)

• Background:

  Protein S100-A8 (Mrp8) contains 2 EF-hand domains and belongs to the S-100 family. Mrp8 binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. It may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.

• Abbreviation:

  S100A8; CAGA

• Synonyms:

  60B8Ag; AI323541; B8Ag; CFAg; CP; Caga; Calgranulin-A; Chemotactic cytokine CP-10; Leukocyte L1 complex light chain; MRP-8; Migration inhibitory factor-related protein 8; Mrp8; Pro-inflammatory S100 cytokine; Protein S100-A8; S100 calcium-binding protein A8; S100a8

• UniProt:

  P27005

• Accession Number:

  P50115

• Expression System:

  E.coli

• Tag:

  C-His

• Sequence:

  Met1-Glu89

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  11.3 kDa

• Observed Molecular Weight:

  13 kDa

• Species:

  Mouse