Recombinant Mouse PCSK9/NARC1 Protein (His Tag)

• Background:

  Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis.PCSK9 also plays a role in neural development.

• Abbreviation:

  PCSK9; NARC1

• Synonyms:

  FH3; HCHOLA3; NARC-1; Narc1; Neural Apoptosis-Regulated Convertase 1; PC9; Pcsk9; Proprotein Convertase 9; Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9

• UniProt:

  Q80W65

• Accession Number:

  Q80W65

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Sequence:

  Gln35-Gln155&Ser156-Gln694

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Not Applicable

• Shipping Conditions:

  This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

• Storage Conditions:

  Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

• Calculated Molecular Weight:

  14&58.2 kDa

• Observed Molecular Weight:

  19&60 kDa

• Formulation:

  Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.

• Species:

  Mouse