Recombinant Human KLK-8/Kallikrein-8 Protein (His Tag)

• Background:

  Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.

• Abbreviation:

  KLK-8; Kallikrein-8

• Synonyms:

  KLK8; Kallikrein-8; NP; NRPN; Neuropsin; Ovasin; PRSS19; Serine Protease 19; Serine Protease TADG-14; TADG14; Tumor-Associated Differentially Expressed Gene 14 Protein; hK8

• UniProt:

  O60259

• Accession Number:

  AAH40887.1

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Sequence:

  Gln29-GLy260

• Field of Research:

  Signal Transduction; Cell biology; Cancer

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Not Applicable

• Shipping Conditions:

  This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

• Storage Conditions:

  Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

• Calculated Molecular Weight:

  26.0 kDa

• Observed Molecular Weight:

  35 kDa

• Formulation:

  Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

• Species:

  Human