Anti-TNFRSF10B / DR5 monoclonal Antibody

• Description:

  Boster Bio Anti-TNFRSF10B / DR5 monoclonal Antibody catalog # M00410-2. Tested in WB, ICC applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5, KILLER, TRAILR2, TRICK2, ZTNFR9; UNQ160/PRO186;

• Gene Name:

  TNFRSF10B

• UniProt:

  O14763

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant full length Human TNFRSF10B.

• Clonality:

  Monoclonal

• Tissue Specificity:

  Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

• Applications:

  WB, ICC

• Purification:

  The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288) . The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

• Molecular Weight:

  47878 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Tumor necrosis factor receptor superfamily member 10B

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Protein Name:

  Tumor necrosis factor receptor superfamily member 10B