Anti-RAIDD CRADD Antibody

• Description:

  Boster Bio Anti-RAIDD CRADD Antibody catalog # A06509-2. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Death domain-containing protein CRADD; Caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CRADD; RAIDD;

• Gene Name:

  CRADD

• UniProt:

  P78560

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to residues in Human RAIDD.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  WB: 1:500-1:1000

• Form:

  Liquid

• Function:

  Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572) . Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor- mediated signaling pathway (PubMed:8985253) .

• Molecular Weight:

  22745 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Death domain-containing protein CRADD

• Subcellular Location:

  Cytoplasm

• Protein Name:

  Death domain-containing protein CRADD