4-Methylamino antipyrine (hydrochloride) (Standard)

• UNSPSC Description:

  4-Methylamino antipyrine (hydrochloride) (Standard) is the analytical standard of 4-Methylamino antipyrine (hydrochloride). This product is intended for research and analytical applications. 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties[2].

• Target Antigen:

  COX; Drug Metabolite

• Type:

  Reference Standards

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/4-methylamino-antipyrine-hydrochloride-standard.html

• Smiles:

  O=C1N(C2=CC=CC=C2)N(C)C(C)=C1NC.[H]Cl

• Molecular Weight:

  253.73

• References & Citations:

  [1]Burmańczuk A, et al. Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets. J Vet Pharmacol Ther. 2016 Dec;39(6):616-620.|[2]Campos C1, et al. Regulation of cyclooxygenase activity by metamizol. Eur J Pharmacol. 1999 Aug 13;378(3):339-47.|[3]Ariza A, et al. Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole. Sci Rep. 2016 Mar 31;6:23845.

• Shipping Conditions:

  Room temperature

• CAS Number:

  9007-83-4