Anti-Hu CD173 Purified

Anti-Hu CD173 Purified

• Background: CD173 (blood group antigen H2) is a fucosylated saccharide (Fuc-alpha-1-2-Gal-beta-1-4-GlcNAc-beta) generated by beta-D-galactoside 2-alpha-L-fucosyltransferase (FUT1). CD173 belongs to markers of early hematopoiesis it is expressed mainly on CD34-positive hematopoietic progenitor cells. CD173 is a precursor structure of CD174 (Lewis Y) and is also structurally related to CD15 (Lewis X). On endothelial cells CD173 and CD174 are concentrated on pseudopodial extensions responsible for initial contacts between endothelial cells.
• Specifications: The antibody MEM-195 reacts with CD173 (H2), an extracellular saccharide antigen expressed mainly during early hematopoiesis it is also expressed on endothelial cells.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Human thrombocytes
• Target Antigen: CD173
• Isotype: IgM
• Clone: MEM-195
• Applications: Flow cytometry: Recommended dilution: 2-5 μg/mL.
• Validated Applications: FC
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
• Other References: *Moehler TM, Sauer S, Witzel M, Andrulis M, Garcia-Vallejo JJ, Grobholz R, Willhauck-Fleckenstein M, Greiner A, Goldschmidt H, Schwartz-Albiez R: Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis. J Cell Physiol. 2008 Apr215(1):27-36., URL: https://www.ncbi.nlm.nih.gov/pubmed/18205178?itool,*Cao Y, Merling A, Karsten U, Schwartz-Albiez R: The fucosylated histo-blood group antigens H type 2 (blood group O, CD173) and Lewis Y (CD174) are expressed on CD34+ hematopoietic progenitors but absent on mature lymphocytes. Glycobiology. 2001 Aug11(8):677-83., URL: https://www.ncbi.nlm.nih.gov/pubmed/11479278?itool,
• Storage Conditions: Store at 2-8°C. Do not freeze.