Anti-Hu PDPN (cancer type) Purified

Anti-Hu PDPN (cancer type) Purified

• Background: PDPN (podoplanin) is a type I transmembrane glycoprotein of mucin-type character. The specific function of this protein has not been determined, but its homologs in other species were described as differentiation antigens. PDPN can be used as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Specifications: The mouse monoclonal antibody LpMab-23 recognizes an extracellular epitope on human cancer type PDPN, a transmembrane glycoprotein, serving as a prognostic marker of oral carcinoma. This antibody recognizes an altered glycosylation pattern that occurs on oral cancer cells and it shows minimal reactivity with the surrounding non-cancerous tissue.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: recombinant human PDPN
• Target Antigen: PDPN (cancer type)
• Isotype: Igg1 κ
• Clone: LpMab-23
• Applications: Flow cytometry: Recommended dilution: 1-5 μg/mL.
• Validated Applications: WB, FC, IHC
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Miyazaki A, Nakai H, Sonoda T, Hirohashi Y, Kaneko MK, Kato Y, Sawa Y, Hiratsuka H: LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer. Oncotarget 2018 Apr 209(30):21156-21165. , URL: https://pubmed.ncbi.nlm.nih.gov/29765527/,*Furusawa Y, Yamada S, Nakamura T, Sano M, Sayama Y, Itai S, Takei J, Harada H, Fukui M, Kaneko MK, Kato Y: PMab-235: A monoclonal antibody for immunohistochemical analysis against goat podoplanin. Heliyon 2019 Jul 105(7):e02063. doi: 10.1016/j.heliyon.2019.e02063, URL: https://pubmed.ncbi.nlm.nih.gov/31338471/,
• Storage Conditions: Store at 2-8°C. Do not freeze.