Anti-Hu CD218a Purified

Anti-Hu CD218a Purified

• Background: CD218a, an approximately 62 kDa type I transmembrane glycoprotein, is the alpha subunit of IL-18 receptor heterodimer. It is expressed in various immune cells, including lymphocytes, NK cells, and myeloid cells, as well as in heart, lung, liver, gut and another tissues. IL-18 is a proinflammatory cytokine, that promotes both Th1 and Th2 immune responses, induces IFN-gamma production and activates NK cells.
• Specifications: The mouse monoclonal antibody H44 recognizes an extracellular epitope of CD218a, the alpha subunit of IL-18 receptor.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Human CD218a expressed on a transfected NK0 cell line
• Target Antigen: CD218a
• Isotype: Igg1 κ
• Clone: H44
• Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
• Validated Applications: WB, IHC-P, FC, IP, IHC-F
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Wu Z, Valentina V, Chen J, Sun W, Lin Z, Keyvanfar K, Talasani N, Kajigaya S, Feng X, Young NS: Interleukin-18 plays a dispensable role in murine and likely also human bone marrow failure. Exp Hematol. 2019 Jan69:54-64.e2., URL: https://pubmed.ncbi.nlm.nih.gov/30316805/#affiliation-1,
• Storage Conditions: Store at 2-8°C. Do not freeze.