Anti-Hu CD172g Purified

Anti-Hu CD172g Purified

• Background: CD172g is a transmembrane glycoprotein, which may play a role in inter-T cellular signaling by binding CD47, and thus in influencing T cell behaviour. CD172g is expressed on mature thymocytes, CD4+ T cells, CD8+ T cells, NK cells, and some B cells. It is absent on myeloid cells. Engagement of CD172g by CD47 expressed on antigen presenting cells results in enhanced antigen-specific T cell proliferation and costimulates T cell activation.
• Specifications: The mouse monoclonal antibody OX-119 recognizes an extracellular epitope on CD172g, an approximately 55 kDa transmembrane glycoprotein expressed on most T cells, as well as on NK cells and some B cell populations.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: recombinant human CD172g
• Target Antigen: CD172g
• Isotype: IgG1
• Clone: OX-119
• Applications: Flow cytometry: Recommended dilution: 1-4 µg/mL
• Validated Applications: FC, IP
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Nettleship JE, Ren J, Rahman N, Berrow NS, Hatherley D, Barclay AN, Owens RJ: A pipeline for the production of antibody fragments for structural studies using transient expression in HEK 293T cells. Protein Expr Purif. 2008 Nov62(1):83-9, URL: https://pubmed.ncbi.nlm.nih.gov/18662785/,*Brooke G, Holbrook JD, Brown MH, Barclay AN: Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. J Immunol. 2004 Aug 15173(4):2562-70 , URL: https://pubmed.ncbi.nlm.nih.gov/15294972/,
• Storage Conditions: Store at 2-8°C. Do not freeze.