Anti-Hu CD119 Purified

Anti-Hu CD119 Purified

• Background: CD119 (alpha subunit of interferon gamma receptor) is a type I transmembrane glycoprotein, which associates with IFNgammaAF1 to form functional receptor for interferon gamma, although CD119 alone is able to bind the cytokin. It is expressed on monocytes, macrophages, lymphocytes, NK cells, neutrophils, fibroblasts, epithelial and endothelial cells, as well as in many tumours.
• Specifications: The mouse monoclonal antibody GIR-208 recognizes an epitope within extracellular part of CD119, a transmembrane glycoprotein of cytokine receptor family.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: CD119 purified from human placenta
• Target Antigen: CD119
• Isotype: IgG1
• Clone: GIR-208
• Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
• Validated Applications: WB, FC, IP
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Fujii K, Miyahara Y, Harada N, Muraoka D, Komura M, Yamaguchi R, Yagita H, Nakamura J, Sugino S, Okumura S, Imoto S, Miyano S, Shiku H: Identification of an immunogenic neo-epitope encoded by murine sarcoma using CXCR3 ligand mRNAs as sensors. Oncoimmunology. 2017 Mar 206(5):e1306617., URL: https://pubmed.ncbi.nlm.nih.gov/28638727/?from_term=fujii+k+miyahara+y&from_pos=4,*Alavi S, Stewart AJ, Kefford RF, Lim SY, Shklovskaya E, Rizos H: Interferon signaling is frequently downregulated in melanoma. Front Immunol. 2018 Jun 219:1414. , URL: https://pubmed.ncbi.nlm.nih.gov/29977240/?from_term=alavi+s+kefford+rf&from_pos=1,*Crescioli C, Cosmi L, Borgogni E, Santarlasci V, Gelmini S, Sottili M, Sarchielli E, Mazzinghi B, Francalanci M, Pezzatini A, Perigli G, Vannelli GB, Annunziato F, Serio M: Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. Endocrinol. 2007 Oct195(1):145-55., URL: https://pubmed.ncbi.nlm.nih.gov/17911406/?from_term=crescioli+c+cosmi+l&from_pos=4,*Igarashi T, Teramoto K, Ishida M, Hanaoka J, Daigo Y: The mechanism of de novo expression of programmed cell death-ligand 1 in squamous cell carcinoma of the lung. Oncol Rep. 2017 Oct38(4):2189-2196., URL: https://pubmed.ncbi.nlm.nih.gov/28791392/?from_term=igarashi+t+teramoto+k&from_pos=7,*Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R: Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro. J Virol. 2015 Jul89(14):7433-8., URL: https://pubmed.ncbi.nlm.nih.gov/25972537/?from_term=hoh+a+&from_pos=9,*El Darzi E, Bazzi S, Daoud S, Echtay KS, Bahr GM: Differential regulation of surface receptor expression, proliferation, and apoptosis in HaCaT cells stimulated with interferon-γ, interleukin-4, tumor necrosis factor-α, or muramyl dipeptide. Int J Immunopathol Pharmacol. 2017 Jun30(2):130-145. , URL: https://pubmed.ncbi.nlm.nih.gov/28449603/?from_term=bazzi+s+&from_page=2&from_pos=1,
• Storage Conditions: Store at 2-8°C. Do not freeze.