Anti-Hu CD66c Purified

Anti-Hu CD66c Purified

• Background: CD66c is a GPI-anchored glycoprotein capable of homophilic adhesion and heterophilic binding to CD66a-e, CD62E, and galectins. It is expressed on granulocytes and epithelial cells, and has potential applications in the detection of sites of infection and inflammation.
• Specifications: The mouse monoclonal antibody B6.2 recognizes a conformationally dependent epitope of native CD66c, a GPI-anchored extracellular glycoprotein expressed on granulocytes and epithelial cells.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Extracts from human breast carcinoma cells
• Target Antigen: CD66c
• Isotype: Igg1 κ
• Clone: B6.2
• Applications: Flow cytometry: Recommended dilution: 3-12 µg/mL
• Validated Applications: FC, IP
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Szpak CA, Johnston WW, Lottich SC, Kufe D, Thor A, Schlom J: Patterns of reactivity of four novel monoclonal antibodies (B72.3, DF3, B1.1 and B6.2) with cells in human malignant and benign effusions. Acta Cytol. 1984 Jul-Aug28(4):356-67., URL: https://www.ncbi.nlm.nih.gov/pubmed/6205527,*Yamagami S, Yokoo S, Amano S, Ebihara N: Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva. Invest Ophthalmol Vis Sci. 2007 Oct48(10):4476-81., URL: https://www.ncbi.nlm.nih.gov/pubmed/17898268,*Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, Blumberg RS, Kuroki M, Skubitz KM, Bates PA: Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site. Blood. 2001 Sep 198(5):1469-79., URL: https://www.ncbi.nlm.nih.gov/pubmed/11520797,*Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K: Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow. J Biol Chem. 2008 Jun 6283(23):15647-55., URL: https://pubmed.ncbi.nlm.nih.gov/18375392/,
• Storage Conditions: Store at 2-8°C. Do not freeze.