PX-478 hydrochloride

• Description:

  PX-478 hydrochloride is an inhibitor of HIF-1α (IC₅₀ of 20-30 μM) with potential antineoplastic activity. PX-478 inhibits HIF-1alpha protein levels and transactivation in a variety of cancer cell lines. The inhibitory effect of PX-478 on HIF-1alpha levels is primarily due to its inhibition of translation because HIF-1alpha translation continues in hypoxia when translation of most proteins is decreased.

• Shipping Conditions:

  gel pack

• Storage Conditions:

  -20°C

• Shelf Life:

  36 months