ZM447439, Aurora B kinase inhibitor

  • Catalog number
    SIH-489-1MG
  • Price
    Please ask
  • Size
    1 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    331771-20-1
  • Description
    Aurora B kinase inhibitor
  • Molecular weight
    513,6 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    ZM 447439, N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C29H31N5O4
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (TLC)
  • Soluble in
    Soluble in DMSO (25 mg/ml)
  • Physical appearance
    Orange solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
  • PubChem number
    9914412
  • Scientific context
    ZM447439 is a potent and selective inhibitor of Aurora B kinase. ZM447439 induces cell growth arrest mid-way through mitosis, and therefore effectively activates apoptosis.
  • Bibliography
    1. Walsby E., Walsh V., Pepper C., Burnett A., & Mills K. (2008) Haematologica. 93(5): 662–669. 2. Kim K.W., et al. (2007) Int. J. Rad.Oncol. Biol. Phy. 67(5): 1519–1525.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of ZM447439 (SIH-489), a Aurora B kinase inhibitor. CAS #: 331771-20-1. Molecular Formula: C29H31N5O4. Molecular Weight: 513.6 g/mol. Chemical structure of ZM447439, a Aurora B kinase inhibitor (SIH-489). CAS # 331771-20-1. Molecular Formula: C29H31N5O4.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.001
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    ZM447439, Aurora B kinase inhibitor
  • Alternative name
    ZM447439, Aurora B phosphorylation catalyst suppressor
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