Human CellExp™LAG3 /CD223, human recombinant
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Catalog number
7278-50
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Price
Please ask
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Size
50 ug
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Synonyms
LAG3, CD223, FDC
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Alternative_names
LAG3, CD223, FDC
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Description
A protein involved in lymphocyte activation
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Recombinant
Yes
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Source
HEK293 cells
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Purity by SDS PAGE
≥95%
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Assay
SDS-PAGE
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Molecular Weight
47 kDa
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Lyophilized
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Physical form description
Lyophilized from 0.22 um filtered PBS (pH 7.4) with 5% trehalose
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Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4).
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Background Information
Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC. It belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. LAG3/CD223 is one of the inhibitory receptors by negatively regulating cellular proliferation, activation, and homeostasis of T cells. LAG3 can bind to HLA class-II antigens and is involved in lymphocyte activation and autoimmunity. There are now LAG3 targeted therapies both in the clinic and in preclinical development, emphasizing the broad interest in this inhibitory receptor.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
LAG3
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Short name
CellExp™LAG3 /CD223, recombinant
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Humans
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Alternative name
H. sapiens CellExp™lymphocyte-activation gene 3 /CD223, H. sapiens Rec.
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Alternative technique
rec
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Alternative to gene target
lymphocyte-activation gene 3, CD223, LAG3 and IDBG-14994 and ENSG00000089692 and 3902, MHC class II protein binding, Cell surfaces, Lag3 and IDBG-188462 and ENSMUSG00000030124 and 16768, BT.18959 and IDBG-640276 and ENSBTAG00000034295 and 515155
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Gene info
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Identity
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Gene
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Long gene name
lymphocyte activating 3
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Synonyms gene name
- lymphocyte-activation gene 3
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Synonyms
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Locus
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Discovery year
1991-06-03
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin like domain containing
- CD molecules
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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