Z-Asp-CH2-DCB, Caspase inhibitor
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Catalog number
SIH-206-10MG
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Price
Please ask
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Size
10 mg
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Stock availabilitIn Stock
In Stock
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CAS number
153088-73-4
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Description
Caspase inhibitor
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Molecular weight
454,3 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
(3S)-3-{[(Benzyloxy)carbonyl]amino}-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C20H17Cl2NO7
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Origin
Synthetic
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Purity pourcentage
>99%
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Soluble in
Soluble in methanol (50 mg/ml) or DMSO
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Physical appearance
White to off-white Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
9911778
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Scientific context
Irreversible, cell permeable broad-spectrum caspase inhibitor. Inhibits hypoxia-induced apoptosis in neuroblastoma cells.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Z-Asp-CH2-DCB (SIH-206), a Caspase inhibitor. CAS #: 153088-73-4. Molecular Formula: C20H17Cl2NO7. Molecular Weight: 454.3 g/mol. Chemical structure of Z-Asp-CH2-DCB, a Caspase inhibitor (SIH-206). CAS # 153088-73-4. Molecular Formula: C20H17Cl2NO7.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
Z-Asp-CH2-DCB, Caspase inhibitor
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Alternative name
Z-L-aspartic acid-CH2-DCB, caspase suppressor
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MeSH Data
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Name
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Concept
Scope note:
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
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Tree numbers
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