YK 4 279 for cell activation

YK 4 279 for cell activation is available 2 times from Biovision labs

2846-5 | YK-4-279 for cell activationsize: 5 mg | 180.07 USD

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2846-25 | YK-4-279 for cell activationsize: 25 mg | 539.02 USD

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  • Description
    YK-4-279 is an Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC₅₀ values ranging from 0.5-2 µM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.
  • Peptide sequence
    N/A
  • CAS number
    1037184-44-3
  • Molecular weight
    366.2
  • Category
    Biochemicals
  • Other name
     4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
  • Molecular formula
    C₁₇H₁₃Cl₂NO₄
  • Physical appearance
    White solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥98% by HPLC
  • Reconstitute instructions
    DMSO (>30 mg/ml)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from air and light
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    YK-4-279 for activation
  • Technique
    activation
  • Alternative name
    YK-4-279 to measure cellular activation
  • Tissue
    cell
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