Yersinia pseudotuberculosis serotype IB LPS-assembly lipoprotein lptE (lptE) -Yeast

• Catalog number
  GEN1115183.Yeast
• Price
  Please ask
• Size
  1000ug

• Long name
  Recombinant Yersinia pseudotuberculosis serotype IB LPS-assembly lipoprotein lptE (lptE)
• Alternative names
  LPS-assembly lipoprotein RlpB; LPS-assembly lipoprotein LptE; LPS-assembly lipoprotein RlpB;
• Gene name
  lptE
• Other gene names
  YPTS_1159; lptE;
• General description
  LPS-assembly lipoprotein lptE (lptE) is a recombinant protein expressed in Yeast . The protein can be with or without a His-Tag or other tag in accordance to customer's request. All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility.
• Product category
  Recombinant Proteins
• Expression system
  Yeast
• Available also expressed in
  E Coli ; Yeast ; Baculovirus ; Mammalian Cell
• Purity
  Greater than 90% (determined by SDS-PAGE)
• Form
  Lyophilized protein
• Storage
  This protein can be stored at -20 degrees Celsius. For extended periods of time it is recommended to keep the protein frozen at -40 or -80 degrees Celsius. Avoid cycles of freezing and thawing as they might denaturate the polypeptide chains.
• Applications
  This protein can be used as a positive control for applications such as ELISA, IFA, RIA, Western Blot, etc.
• Gene
  Bacterial pathogen lipopolysaccharides (LPS) are the major outer surface membrane components present in almost all Gram-negative bacteria and act as extremely strong stimulators of innate or natural immunity in diverse eukaryotic species ranging from insects to humans. LPS consist of a poly- or oligosaccharide region that is anchored in the outer bacterial membrane by a specific carbohydrate lipid moiety termed lipid A. The lipid A component is the primary immunostimulatory center of LPS. With respect to immunoactivation in mammalian systems, the classical group of strongly agonistic (highly endotoxin) forms of LPS has been shown to be comprised of a rather similar set of lipid A types. In addition, several natural or derivative lipid A structures have been identified that display comparatively low or even no immunostimulation for a given mammalian species. Some members of the latter more heterogeneous group are capable of antagonizing the effects of strongly stimulatory LPS/lipid A forms. Agonistic forms of LPS or lipid A trigger numerous physiological immunostimulatory effects in mammalian organisms, but--in higher doses--can also lead to pathological reactions such as the induction of septic shock. Cells of the myeloid lineage have been shown to be the primary cellular sensors for LPS in the mammalian immune system. During the past decade, enormous progress has been obtained in the elucidation of the central LPS/lipid A recognition and signaling system in mammalian phagocytes. According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18. The elucidation of structure-activity correlations in LPS and lipid A has not only contributed to a molecular understanding of both immunostimulatory and toxic septic processes, but has also re-animated the development of new pharmacological and immuno-stimulatory strategies for the prevention and therapy of infectious and malignant diseases.

• Gene target
  Yersinia   pseudotuberculosis   serotype   LPS-assembly   lipoprotein   lptE   lptE   Yeast  
• Gene symbol
  IRF6
• Short name
  LPS-assembly lipoprotein lptE (lptE)
• Host
  Yeast, Ascomycota
• Species
  Yeast, Yeasts
• Alternative name
  Yersinia pseudotuberculosis serotype IB LPS-assembly lipoprotein lptE (lptE) -Yeast

Gene info

• Identity
  HGNC:6121
• Gene
  IRF6
• Long gene name
  interferon regulatory factor 6
• Synonyms gene
  • VWS
  • LPS
• Synonyms gene name
  • Van der Woude syndrome
• Synonyms
  • OFC6
  • VWS1
• GenBank acession
  • AL022398
• Locus
  1q32.2
• Discovery year
  1997-10-16
• Entrez gene record
  3664
• Pubmed identfication
  • 12219090
• RefSeq identity
  • NM_006147
• Classification
  • Interferon regulatory factors
• VEGA ID
  OTTHUMG00000036521

MeSH Data

• Name
  Tuberculin Test
• Concept
  Scope note: One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.
• Tree numbers
  • E01.370.225.812.871.800
  • E05.200.812.871.800
  • E05.478.594.890.800
• Qualifiers
  ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data

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