Y-27632, dihydrochloride

  • Catalog number
    1596-1
  • Price
    Please ask
  • Size
    1 mg
  • Alternative_name
    trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochloride
  • Description
    Selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and >250 µM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase, respectively. Prevents apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem cells (hES) without affecting their pluripotency.
  • CAS Number
    146986-50-7
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₄H₂₁N₃O.2HCl
  • Molecular Weight
    320.26
  • Cell Permeable
    Yes
  • Purity
    ≥99% by HPLC
  • Solubilities
    H₂O (100 mM) or PBS (100 mM)
  • Handling
    Protect from air and moisture
  • Tag Line
    A Rho kinase (ROCK) inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    RT
  • Shelf Life
    24months
  • MDL Number
    MFCD03490488
  • PubChem CID
    9901617
  • SMILES
    CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
  • InChi
    InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1
  • InChi Key
    IDDDVXIUIXWAGJ-DDSAHXNVSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    H3Y1, PSMB6, STSP1, SLC7A7, ANOS2P, H3Y2, GPATCH11
  • Short name
    Y-27632, dihydrochloride
  • Alternative name
    Y-27632, dihydrochloride
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    solute carrier family 7 member 7
  • Synonyms gene
  • Synonyms gene name
    • solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1999-01-28
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Solute carriers
  • VEGA ID
  • Locus Specific Databases
Gene info
Gene info
Gene info
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