BRCA2 Antibody

• Catalog number
  bs-1210R
• Price
  Please ask
• Size
  0.1ml

• Long name
  BRCA2 Primary Polyclonal Antibody
• Also known as
  BRCA2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  BRCA2
• Specificity
  This is a highly specific antibody against BRCA2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  1-50/3418
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human BRCA2
• Gene ID number
  675
• Swiss Prot
  P51587
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and DSS1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; BROVCA2; Breast cancer type 2 susceptibility protein; Fanconi anemia group D1 protein; BRCA2
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BRCA2  
• Gene symbol
  BRCA2
• Short name
  Anti-BRCA2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  BRCA2 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  breast cancer 2, early onset, BRCC2 and BROVCA2 and FACD and FAD and FAD1 and FANCD and FANCD1 and GLM3 and PNCA2, BRCA2 and IDBG-22703 and ENSG00000139618 and 675, gamma-tubulin binding, nuclei, Brca2 and IDBG-209587 and ENSMUSG00000041147 and 12190, BRCA2 and IDBG-630223 and ENSBTAG00000000988 and

Gene info

• Identity
  HGNC:1101
• Gene
  BRCA2
• Long gene name
  BRCA2 DNA repair associated
• Synonyms gene
  • FANCD1
  • FACD
  • FANCD
• Synonyms gene name
  • Fanconi anemia, complementation group D1
  • breast cancer 2, early onset
  • breast cancer 2
• Synonyms
  • FAD
  • FAD1
  • BRCC2
  • XRCC11
• Synonyms name
  • BRCA1/BRCA2-containing complex, subunit 2
• GenBank acession
  • U43746
• Locus
  13q13.1
• Discovery year
  1994-10-17
• Entrez gene record
  675
• Pubmed identfication
  • 8091231
  • 7581463
  • 15057823
• RefSeq identity
  • NM_000059
• Classification
  • FA complementation groups
• VEGA ID
  OTTHUMG00000017411
• Locus Specific Databases
  • Breast Cancer
  • Fanconi Anaemia Mutation Database
  • BRCA1 database at LOVD-China
  • Global Variome shared LOVD
  • LOVD - Leiden Open Variation Database
  • Global Variome shared LOVD
  • LRG_293

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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