Xanthohumol, Autophagy inhibitor
-
Catalog number
SIH-370-10MG
-
Price
Please ask
-
Size
10 mg
-
-
Stock availabilitIn Stock
In Stock
-
CAS number
6754-58-1
-
Description
Autophagy inhibitor
-
Molecular weight
354,4 g/mol
-
Primary research fields
Cancer, Autophagy
-
Other name
(2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
-
Product category
Small Molecules
-
Product type
Inhibitor
-
Chemical formula
C21H22O5
-
Origin
Synthetic
-
Purity pourcentage
≥98% (TLC); NMR (Conforms)
-
Soluble in
May be dissolved in DMSO (35 mg/ml) or Ethanol (35 mg/ml)
-
Physical appearance
Yellow solid
-
Storage recommendations
-20ºC
-
Shipping recommendations
Shipped Ambient
-
Safety information
Classification: Toxic Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H317 May cause an allergic skin reaction. H400 Very toxic to aquatic life. Precautionary Phrases: P273 Avoid release to the environment. P280 Wear protective gloves.
-
PubChem number
639665
-
Scientific context
Xanthohumol is a valosin-containing protein (VCP) inhibitor which binds to the N-domain of VCP, suppressing function and impairing autophagosome maturation (1). It also inhibits growth of a wide variety of human cancer cell lines by inhibiting proliferation and inducing apoptosis (2).
-
Bibliography
1. Sasazawa Y., et al. (2012) ACS Chem Biol. 7(5): 892-900. 2. Vene R., et al. (2012) Mol. Med. 18: 1292.
-
Release date
4-Apr-2013
-
PubMed number
Refer to PubMed
-
Tested applications
To be tested
-
Tested reactivity
To be tested
-
-
Representative figure legend
Chemical structure of Xanthohumol (SIH-370), a Autophagy inhibitor. CAS #: 6754-58-1. Molecular Formula: C21H22O5. Molecular Weight: 354.4 g/mol. Chemical structure of Xanthohumol, a Autophagy inhibitor (SIH-370). CAS # 6754-58-1. Molecular Formula: C21H22O5.
-
Warning information
Non-hazardous
-
Country of production
Canada
-
Total weight kg
0.25
-
Net weight g
0.01
-
-
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Gene target
-
Short name
Xanthohumol, Autophagy inhibitor
-
Alternative name
Xanthohumol, Autophagy suppressor
-
Similar products