Xanthohumol, Autophagy inhibitor

  • Catalog number
    SIH-370-10MG
  • Price
    Please ask
  • Size
    10 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    6754-58-1
  • Description
    Autophagy inhibitor
  • Molecular weight
    354,4 g/mol
  • Primary research fields
    Cancer, Autophagy
  • Other name
    (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(­3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-­2-propen-1-one
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C21H22O5
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (TLC); NMR (Conforms)
  • Soluble in
    May be dissolved in DMSO (35 mg/ml) or Ethanol (35 mg/ml)
  • Physical appearance
    Yellow solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Toxic Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H317 May cause an allergic skin reaction. H400 Very toxic to aquatic life. Precautionary Phrases: P273 Avoid release to the environment. P280 Wear protective gloves.
  • PubChem number
    639665
  • Scientific context
    Xanthohumol is a valosin-containing protein (VCP) inhibitor which binds to the N-domain of VCP, suppressing function and impairing autophagosome maturation (1). It also inhibits growth of a wide variety of human cancer cell lines by inhibiting proliferation and inducing apoptosis (2).
  • Bibliography
    1. Sasazawa Y., et al. (2012) ACS Chem Biol. 7(5): 892-900. 2. Vene R., et al. (2012) Mol. Med. 18: 1292.
  • Release date
    4-Apr-2013
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of Xanthohumol (SIH-370), a Autophagy inhibitor. CAS #: 6754-58-1. Molecular Formula: C21H22O5. Molecular Weight: 354.4 g/mol. Chemical structure of Xanthohumol, a Autophagy inhibitor (SIH-370). CAS # 6754-58-1. Molecular Formula: C21H22O5.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.01
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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