WHI P131, JAK3 kinase inhibitor

• Catalog number
  SIH-485-10MG
• Price
  Please ask
• Size
  10 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  202475-60-3
• Description
  JAK3 kinase inhibitor
• Molecular weight
  297,3 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  WHI-P131, Janex 1, 4-​[(6,​7-​dimethoxy-​4-​quinazolinyl)amino]-​phenol
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C16H15N3O3
• Origin
  Synthetic
• Purity pourcentage
  ≥98%
• Soluble in
  Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml)
• Physical appearance
  White to off-white solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  3794
• Scientific context
  WHI P131 also known as Janex-1, is a reversible, potent, and specific inhibitor of JAK3. WHI P131 is cell permeable. It has been seen to inhibit glioblastoma cell adhesion and migration, as well as, thrombin-induced platelet aggregation.
• Bibliography
  1. Sudbeck E.A., et al. (1999) Clin. Cancer Res: J. Am. Asso. Cancer Res. 5(6): 1569–1582.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of WHI P131 (SIH-485), a JAK3 kinase inhibitor. CAS #: 202475-60-3. Molecular Formula: C16H15N3O3. Molecular Weight: 297.3 g/mol. Chemical structure of WHI P131, a JAK3 kinase inhibitor (SIH-485). CAS # 202475-60-3. Molecular Formula: C16H15N3O3.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.01
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  WHI   P131   JAK3   kinase   inhibitor  
• Gene symbol
  JAK3
• Short name
  WHI P131, JAK3 kinase inhibitor
• Alternative name
  WHI P131, Janus kinase 3 phosphorylation catalyst suppressor
• Alternative to gene target
  Janus kinase 3, JAK-3 and JAK3_HUMAN and JAKL and L-JAK and LJAK, JAK3 and IDBG-37201 and ENSG00000105639 and 3718, transferase activity, Plasma membranes, Jak3 and IDBG-166648 and ENSMUSG00000031805 and 16453, BT.44422 and IDBG-641863 and ENSBTAG00000020904 and 538276

Gene info

• Identity
  HGNC:6193
• Gene
  JAK3
• Long gene name
  Janus kinase 3
• Synonyms
  • L-JAK
  • JAKL
  • LJAK
  • JAK3_HUMAN
  • JAK-3
• Synonyms name
  • tyrosine-protein kinase JAK3
  • leukocyte Janus kinase
• GenBank acession
  • U31601
• Locus
  19p13.11
• Discovery year
  1994-12-19
• Entrez gene record
  3718
• Pubmed identfication
  • 8921370
  • 9226382
• RefSeq identity
  • NM_000215
• Classification
  • Jak family tyrosine kinases
• VEGA ID
  OTTHUMG00000165648
• Locus Specific Databases
  • JAK3base: Mutation registry for autosomal recessive severe combined JAK3 deficiency
  • LRG_77

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