VX 809 for cell activation

VX 809 for cell activation is available 2 times from Biovision labs

2857-5 | VX-809 for cell activationsize: 5 mg | 218.72 USD

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2857-25 | VX-809 for cell activationsize: 25 mg | 691.43 USD

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  • Description
    VX-809 is a novel CFTR corrector that modulates the folding and trafficking of CFTR protein. VX-809 stabilizes an N-terminal domain in CFTR that contains only MSD1 (membrane-spanning domain 1) and efficaciously restores function to CFTR forms that have missense mutations in MSD1. The action of VX-809 on MSD1 appears to suppress folding defects in F508del-CFTR by enhancing interactions among the NBD1, MSD1, and MSD2 domains.
  • Peptide sequence
    N/A
  • CAS number
    936727-05-8
  • Molecular weight
    452.41
  • Category
    Biochemicals
  • Other name
    3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid; Lumacaftor
  • Molecular formula
    C₂₄H₁₈F₂N₂O₅
  • Physical appearance
    White to off-white solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥98% by HPLC
  • Reconstitute instructions
    DMSO (>90 mg/ml)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from air and light
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    VX-809 for activation
  • Technique
    activation
  • Alternative name
    VX-809 to measure cellular activation
  • Tissue
    cell
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