VEGF121 Recombinant Protein

• Catalog number
  40-163
• Price
  Please ask
• Size
  0.002 mg, 0.01 mg

• About recombinant protein
  VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant human VEGF121 is a 28.4 kDa disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.
• Other name of the recombinant
  VPF, VEGF, MVCD1, Vascular endothelial growth factor A, Vascular permeability factor, VEGF-A
• Recombinant in
  E. coli
• SEQUENCE
  APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR R
• Activity
  Biological activity was determined by the dose - dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2 - 0.4 ng/mL.
• Keep at
  The lyophilized VEGF121 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted VEGF121 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing VEGF121 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  76781487
• Accession nr
  NP_001028928.1
• Pureity
  Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
• About
  This product is for research use only.
• Protein s origin
  Human
• Vial
  Lyophilized
• NCBI ID
  7422
• Gene name
  vascular endothelial growth factor A
• Source
  Homo sapiens
• Uniprot
  P15692-9
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  VEGF121   Protein  
• Gene symbol
  VEGFA
• Short name
  VEGF121 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  VEGF121 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:12680
• Gene
  VEGFA
• Long gene name
  vascular endothelial growth factor A
• Synonyms gene
  • VEGF
• Synonyms gene name
  • vascular endothelial growth factor
• Synonyms
  • VEGF-A
  • VPF
• GenBank acession
  • AB021221
• Locus
  6p21.1
• Discovery year
  1994-01-10
• Entrez gene record
  7422
• Pubmed identfication
  • 8786112
• RefSeq identity
  • NM_001025366
• Classification
  • VEGF family
• VEGA ID
  OTTHUMG00000014745
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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