VEGFR1 Antibody

• Catalog number
  bs-0170R
• Price
  Please ask
• Size
  0.1ml

• Long name
  VEGFR1 Primary Polyclonal Antibody
• Also known as
  VEGFR1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  VEGFR1
• Specificity
  This is a highly specific antibody against VEGFR1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  1160-1210/1333
• Subcellular location
  Cytoplasm
• Source
  KLH conjugated synthetic peptide derived from rat VEGFR1
• Gene ID number
  54251
• Swiss Prot
  P53767
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC, YES1 and PLCG, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  VEGFR-1; Vascular endothelial growth factor receptor 1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase receptor FLT; Flt1; Vegfr1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  VEGFR1  
• Gene symbol
  FLT1
• Short name
  Anti-VEGFR1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  VEGFR1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3763
• Gene
  FLT1
• Long gene name
  fms related receptor tyrosine kinase 1
• Synonyms gene
  • FLT
• Synonyms gene name
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • fms-related tyrosine kinase 1
  • fms related tyrosine kinase 1
• Synonyms
  • VEGFR1
• Synonyms name
  • vascular endothelial growth factor receptor 1
  • vascular permeability factor receptor
• GenBank acession
  • AF063657
• Locus
  13q12.3
• Discovery year
  1986-01-01
• Entrez gene record
  2321
• Pubmed identfication
  • 2158038
• RefSeq identity
  • NM_002019
• Classification
  • Receptor tyrosine kinases
  • I-set domain containing
• VEGA ID
  OTTHUMG00000016648
• Locus Specific Databases
  • The Globin Gene Server
  • LRG_425

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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