VDAC1 Antibody

• Catalog number
  R32009
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  VDAC1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  Optimal dilution of the VDAC antibody should be determined by the researcher.
• Intented use
  This VDAC antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P21796
• Purity
  Antigen affinity
• Description
  The voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane is a small, abundant outer membrane pore-forming protein found in the outer membranes of all eukaryotic mitochondria. The VDAC protein is thought to form the major pathway for movement of adenine nucleotides through the outer membrane and to be the mitochondrial binding site for hexokinase and glycerol kinase. At low transmembrane voltage, VDAC is open for anions such as phosphate, chloride, and adenine nucleotides. At higher transmembrane voltage, VDAC functions as a selective channel for cations and uncharged molecules. These features make VDAC likely to play a role in mitochondrial energy metabolism. Huizing et al. studied by Northern and Western blot analyses the human tissue distribution of mitochondrial transmembrane metabolite carriers. They found that VDAC1 mRNA has a ubiquitous distribution, with most pronounced expression in heart, liver, and skeletal muscle, whereas the VDAC2 isoform appears to be expressed only in the heart.
• Immunogen
  Amino acids QMNFETAKSRVTQSNFAVGYKTDEFQLH of human VDAC/Porin were used as the immunogen for the VDAC antibody.
• Storage
  After reconstitution, the VDAC antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Localization
  Cytoplasmic
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  VDAC1  
• Gene symbol
  VDAC1
• Short name
  Anti-VDAC1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to VDAC1
• Alternative technique
  antibodies
• Alternative to gene target
  voltage-dependent anion channel 1, PORIN and VDAC-1, VDAC1 and IDBG-240337 and ENSG00000213585 and 7416, porin activity, nuclei, Vdac1 and IDBG-171107 and ENSMUSG00000020402 and 22333, VDAC1 and IDBG-645740 and ENSBTAG00000013113 and 282119

Gene info

• Identity
  HGNC:12669
• Gene
  VDAC1
• Long gene name
  voltage dependent anion channel 1
• Synonyms
  • MGC111064
  • PORIN
• Locus
  5q31.1
• Discovery year
  1993-11-02
• Entrez gene record
  7416
• Pubmed identfication
  • 7517385
• Classification
  • Voltage dependent anion channels
• VEGA ID
  OTTHUMG00000129118

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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