VAV3(Tyr141) Antibody, ALEXA FLUOR 647

  • Catalog number
    bs-10271R-A647
  • Price
    Please ask
  • Size
    100ul
  • Long name
    VAV3(Tyr141) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
  • Also known as
    Anti-VAV3 Tyr141 PAb ALEXA FLUOR 647
  • Category
    Conjugated Primary Antibodies
  • Conjugated with
    ALEXA FLUOR® 647
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    VAV3 Tyr141
  • Specificity
    This is a highly specific antibody against VAV3 Tyr141.
  • Modification
    Phosphorylation
  • Modification Site
    Tyr141
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Subcellular location
    Cytoplasm
  • Source
    KLH conjugated synthetic phosphopeptide derived from human VAV3 around the phosphorylation site of Tyr141
  • Gene ID Number
    10451
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge; Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission
    650nm/665nm
  • Synonyms
    VAV3phospho Y141; Guanine nucleotide exchange factor VAV3; Protein vav 3; Protein vav3; VAV 3; Vav 3 guanine nucleotide exchange factor; VAV 3 oncogene; VAV 3 protein; VAV-3; Vav3; VAV3 oncogene; VAV3 protein; VAV3_HUMAN.
  • Properties
    For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-VAV3 Tyr141 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugation
    Alexa Fluor, ALEXA FLUOR 647
  • French translation
    anticorps
  • Gene target
    VAV3   Tyr141  
  • Gene symbol
    VAV3, VAV3-AS1
  • Short name
    Anti-VAV3 Tyr141
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Immunoglobulin G (IgG)
  • Label
    ALEXA FLUOR 647
  • Alternative name
    VAV3(Tyr141) Polyclonal Antibody, ALEXA FLUOR 647
  • Alternative technique
    antibodies
  • Alternative to gene target
    vav 3 guanine nucleotide exchange factor, VAV3 and IDBG-100649 and ENSG00000134215 and 10451, metal ion binding, Plasma membranes, Vav3 and IDBG-188386 and ENSMUSG00000033721 and 57257, VAV3 and IDBG-635847 and ENSBTAG00000031575 and 521961
Gene info
  • Identity
  • Gene
  • Long gene name
    vav guanine nucleotide exchange factor 3
  • Synonyms gene name
    • vav 3 oncogene
    • vav 3 guanine nucleotide exchange factor
  • GenBank acession
  • Locus
  • Discovery year
    1999-07-07
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Dbl family Rho GEFs
    • Pleckstrin homology domain containing
    • MicroRNA protein coding host genes
    • SH2 domain containing
  • VEGA ID
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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