VAV3 Antibody, HRP Conjugated

• Catalog number
  bs-4286R-HRP
• Price
  Please ask
• Size
  0.1ml

• Long name
  VAV3 Polyclonal Antibody, HRP Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  HRP
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  VAV3
• Specificity
  This is a highly specific antibody against VAV3.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  710-760/847
• Subcellular location
  Cytoplasm
• Source
  KLH conjugated synthetic peptide derived from mouse VAV3
• Gene ID number
  57257
• Swiss Prot
  Q9R0C8
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  Idd18.1; AA986410; A530094I06Rik; Guanine nucleotide exchange factor VAV3; VAV-3; Vav3
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
• Additional conjugation
  HRP Conjugated
• French translation
  anticorps

• Gene target
  VAV3   Conjugated  
• Gene symbol
  VAV3, VAV3-AS1
• Short name
  Anti-VAV3
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  HRP
• Alternative name
  Anti-VAV3 PAb HRP
• Alternative technique
  antibodies
• Alternative to gene target
  vav 3 guanine nucleotide exchange factor, VAV3 and IDBG-100649 and ENSG00000134215 and 10451, metal ion binding, Plasma membranes, Vav3 and IDBG-188386 and ENSMUSG00000033721 and 57257, VAV3 and IDBG-635847 and ENSBTAG00000031575 and 521961

Gene info

• Identity
  HGNC:12659
• Gene
  VAV3
• Long gene name
  vav guanine nucleotide exchange factor 3
• Synonyms gene name
  • vav 3 oncogene
  • vav 3 guanine nucleotide exchange factor
• GenBank acession
  • AF118886
• Locus
  1p13.3
• Discovery year
  1999-07-07
• Entrez gene record
  10451
• RefSeq identity
  • NM_006113
• Classification
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
  • MicroRNA protein coding host genes
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000010995

Gene info

• Identity
  HGNC:40608
• Gene
  VAV3-AS1
• Long gene name
  VAV3 antisense RNA 1
• Synonyms gene name
  • VAV3 antisense RNA 1 (non-protein coding)
• GenBank acession
  • AA425131
  • BG193383
• Locus
  1p13.3
• Discovery year
  2012-02-24
• Entrez gene record
  100873946
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000010994

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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