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Alternative_name
Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
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Description
A highly selective K⁺- ionophore. It binds potassium ions (K⁺) and facilitates their transfer across lipid bilayers. Inhibits Ca²⁺-ATPase activity and promotes cell death by mitochondrial swelling and autophagic processes, but not apoptosis. Antagonizes endothelin-induced vasoconstriction (IC₅₀ = 0.3 µM).
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CAS Number
2001-95-8
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₅₄H₉₀N₆O₁₈
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Molecular Weight
1111.32
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Cell Permeable
Yes
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Purity
≥99%
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Solubilities
DMSO (25 mM) or EtOH (25 mM)
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Handling
Protect from light and moisture
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Tag Line
A highly selective K⁺- ionophore
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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MDL Number
MFCD00005114
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PubChem CID
5649
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SMILES
CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C
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InChi
InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25 (7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)
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InChi Key
FCFNRCROJUBPLU-UHFFFAOYSA-N
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MSDS Available
Yes
