U0126

• Catalog number
  1668-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene
• Description
  Potent and selective non-competitive inhibitor of MAP kinase kinase(MEK). Inhibits MEK-1 and MEK-2 (IC₅₀ values of 0.07 and 0.06 µM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4.
• CAS Number
  109511-58-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₆N₆S₂
• Molecular Weight
  380.48
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A MEK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD01861186
• PubChem CID
  3006531
• PubChem CID Link
• SMILES
  C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
• InChi
  InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
• InChi Key
  DVEXZJFMOKTQEZ-JYFOCSDGSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  U0126  
• Short name
  U0126
• Alternative name
  U0126

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