Tyrosine Kinase Receptor Antibody ALEXA FLUOR
Tyrosine Kinase Receptor Antibody ALEXA FLUOR is available 5 times from Bioss primary conjugated antibodies. alexa fluor labs
- CategoryConjugated Primary Antibodies
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenTrk A + B + C
- SpecificityThis is a highly specific antibody against Trk A + B + C.
- Modification SiteNone
- ClonePolyclonal antibody
- Concentration1ug per 1ul
- Immunogen range640-676/796
- Subcellular locationCytoplasm
- SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Trk A
- Gene ID Number4914
- Swiss ProtP04629
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- CrossreactivityHuman, Mouse, Rat
- Cross-reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Background of the antigenReceptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
- PurificationPurified by Protein A.
- Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
- SynonymsMTC; TRK; TRK1; TRKA; Trk-A; p14-TrkA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; gp14trk; NTRK1
- Gene target
- Short nameTyrosine Kinase Receptor Antibody,
- Alternative techniqueantibodies
bs-0192R-A350 | Tyrosine Kinase Receptor Antibody, ALEXA FLUOR 350size: 100ul | 409.81 USD
bs-0192R-A488 | Tyrosine Kinase Receptor Antibody, ALEXA FLUOR 488size: 100ul | 409.81 USD
bs-0192R-A555 | Tyrosine Kinase Receptor Antibody, ALEXA FLUOR 555size: 100ul | 409.81 USD
bs-0192R-A594 | Tyrosine Kinase Receptor Antibody, ALEXA FLUOR 594size: 100ul | 409.81 USD
bs-0192R-A647 | Tyrosine Kinase Receptor Antibody, ALEXA FLUOR 647size: 100ul | 409.81 USD
- Catalog numberbs-0192R-A647
- Price409.81 USD
1. Gene info
- Long gene nameleukocyte receptor tyrosine kinase
- Synonyms gene name
- leukocyte tyrosine kinase
- GenBank acession
- Discovery year1991-06-28
- Entrez gene record
- Pubmed identfication
- Receptor Tyrosine Kinases
- Havana BLAST/BLAT
- ConceptScope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
- Tree numbers
- Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
- Entrez Gene