TYRO3 Antibody, ALEXA FLUOR 350

• Catalog number
  bs-6780R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  TYRO3 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-TYRO3 PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  TYRO3
• Specificity
  This is a highly specific antibody against TYRO3.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  30-80/890
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tyrosine-protein kinase receptor TYRO3
• Gene ID Number
  7301
• Swiss Prot
  Q06418
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; TYRO3
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• French translation
  anticorps

• Gene target
  TYRO3  
• Gene symbol
  TYRO3
• Short name
  Anti-TYRO3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  TYRO3 Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies
• Alternative to gene target
  TYRO3 protein tyrosine kinase, BYK and Dtk and RSE and Sky and Tif, TYRO3 and IDBG-7206 and ENSG00000092445 and 7301, transferase activity, nuclei, Tyro3 and IDBG-199993 and ENSMUSG00000027298 and 22174, TYRO3 and IDBG-646302 and ENSBTAG00000001694 and 788224

Gene info

• Identity
  HGNC:12446
• Gene
  TYRO3
• Long gene name
  TYRO3 protein tyrosine kinase
• Synonyms gene
  • RSE
• Synonyms
  • Dtk
  • Brt
  • Tif
  • Sky
  • Etk-2
  • Rek
• GenBank acession
  • D50479
• Locus
  15q15.1
• Discovery year
  1992-10-02
• Entrez gene record
  7301
• Pubmed identfication
  • 7851890
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000130341

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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