Twinkle ATXN8 Antibody Conjugated
7x Twinkle ATXN8 Antibody Conjugated found in Bioss Primary Conjugated Antibodies
- CategoryConjugated Primary Antibodies
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenTwinkle/ATXN8
- SpecificityThis is a highly specific antibody against Twinkle/ATXN8.
- Modification siteNone
- ClonePolyclonal antibody
- Concentration1ug per 1ul
- SourceKLH conjugated synthetic peptide derived from human Twinkle/ATXN8
- CrossreactivityHuman, Mouse, Rat
- Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Antigen backgroundTwinkle, also known as PEO1 (Progressive external ophthalmoplegia 1 protein), PEOA3, SANDO or TWINL, is a mitochondrial protein that functions as a 5â€™-3â€™ nucleotide-dependent DNA helicase. Colocalized with mtDNA (mitochondrial DNA) in mitochondrial nucleoids, Twinkle is important in the metabolism and maintenance of mtDNA, playing a crucial role in the regulation of mtDNA copy numbers. Twinkle is expressed at high levels in testis, pancreas and skeletal muscle and exists as three isoforms due to alternative splicing events. Defects in the gene encoding Twinkle are the cause of two conditions: progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant 3 (PEOA3) and sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO). PEOA3 is characterized by ptosis and weak muscles, while SANDO is characterized by ophthalmoparesis, dysarthria and sensory ataxic neuropathies.
- Purification methodThis antibody was purified via Protein A.
- SynonymsAtaxin 8;Ataxin8;ATXN 8;ATXN8;C10 orf2;C10orf 2;C10orf2;Chromosome 10 open reading frame 2;IOSCA;PEO 1;PEO;PEO1;PEOA3;Progressive external ophthalmoplegia 1 protein;SANDO;SCA 8;SCA8;T7 gp4 like protein with intramitochondrial nucleoid localization;T7 like mitochondrial DNA helicase;Twinkle protein, mitochondrial;TWINL.
- Gene target
- Alternative techniqueantibodies
bs-11775R-Biotin | Twinkle/ATXN8 Antibody, Biotin Conjugated0.1ml 407.26 USD
bs-11775R-Cy3 | Twinkle/ATXN8 Antibody, Cy3 Conjugated0.1ml 428.05 USD
- Catalog numberbs-11775R-Cy3
- Price428.05 USD
- Long nameTwinkle/ATXN8 Polyclonal Antibody, Cy3 Conjugated
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
- Excitation Emission512,550nm/570,615nm
- PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Twinkle/ATXN8 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
- Additional conjugationcy3 conjugation kit
- French translationanticorps
- Short nameTwinkle/ATXN8 Antibody, Conjugated
- TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
- Alternative nameTwinkle/ATXN8 (Antibody to), cyanine 3 coupled
1. Gene info
- Long gene nameataxin 8
- GenBank acession
- Discovery year2006-07-18
- Entrez gene record
- Pubmed identfication
- ConceptScope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
- Tree numbers
- Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
bs-11775R-Cy5 | Twinkle/ATXN8 Antibody, Cy5 Conjugated0.1ml 428.05 USD
bs-11775R-Cy5.5 | Twinkle/ATXN8 Antibody, Cy5.5 Conjugated0.1ml 428.05 USD
bs-11775R-Cy7 | Twinkle/ATXN8 Antibody, Cy7 Conjugated0.1ml 428.05 USD
bs-11775R-FITC | Twinkle/ATXN8 Antibody, FITC Conjugated0.1ml 407.26 USD
bs-11775R-HRP | Twinkle/ATXN8 Antibody, HRP Conjugated0.1ml 428.05 USD
Supplier:Bioss Primary Conjugated Antibodies