TSEN2 Antibody

• Catalog number
  bs-9735R
• Price
  Please ask
• Size
  0.1ml

• Long name
  TSEN2 Primary Polyclonal Antibody
• Also known as
  TSEN2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  TSEN2
• Specificity
  This is a highly specific antibody against TSEN2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TSEN2
• Gene ID number
  80746
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The tRNA-splicing endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5’ and 3’ splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the heterotetrameric endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. TSEN2 (tRNA-splicing endonuclease subunit Sen2), also known as tRNA-intron endonuclease Sen2, is a 465 amino acid nuclear protein that constitutes one of the two catalytic subunits of the tRNA-splicing endonuclease complex. There are three isoforms of TSEN2 that are produced as a result of alternative splicing events. Isoform 1 seems to carry the active site for 5’-splice site cleavage. Defects in the gene encoding TSEN2 are the cause of pontocerebellar hypoplasia type 2B, which is characterized by progressive microencephaly with epilepsy, extrapyramidal dyskinesia and chorea without spinal cord findings.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  HsSen2; MGC2776; MGC4440; SEN2; SEN2L; tRNA intron endonuclease Sen2; tRNA splicing endonuclease 2 homolog SEN2, S. cerevisiae; tRNA splicing endonuclease subunit Sen2; TSEN 2; SEN2_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TSEN2  
• Gene symbol
  TSEN2
• Short name
  Anti-TSEN2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  TSEN2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:28422
• Gene
  TSEN2
• Long gene name
  tRNA splicing endonuclease subunit 2
• Synonyms gene name
  • tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae)
  • tRNA splicing endonuclease 2 homolog (S. cerevisiae)
  • TSEN2 tRNA splicing endonuclease subunit
• Synonyms
  • SEN2
  • SEN2L
  • MGC2776
• GenBank acession
  • BC019582
• Locus
  3p25.2
• Discovery year
  2005-03-07
• Entrez gene record
  80746
• Pubmed identfication
  • 15109492
• RefSeq identity
  • NM_025265
• Classification
  • tRNA-splicing endonuclease subunits
• VEGA ID
  OTTHUMG00000129765

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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