TSC1 (357CT4.4.2) Monoclonal Antibody

• Catalog number
  bsm-51109M
• Price
  Please ask
• Size
  0.1ml

• Long name
  TSC1 (357CT4.4.2) Monoclonal Antibody
• Also known as
  TSC1 (357CT4.4.2) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  TSC1
• Specificity
  This is a highly specific antibody against TSC1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  357CT4.4.2
• Source
  Purified His-tagged TSC1 protein(Fragment) was used to produced this monoclonal antibody.
• Gene ID number
  7248
• Swiss Prot
  Q92574
• Tested Applications
  WB
• Recommended dilutions
  WB(1:100~250)
• Cross reactivity
  Human, Mouse
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
• Purification method
  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  LAM; TSC; Hamartin; Tuberous sclerosis 1 protein; TSC1; KIAA0243
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  TSC1   357CT4   Monoclonal  
• Gene symbol
  TSC1
• Short name
  Anti-TSC1
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)2b
• Alternative name
  TSC1 (357CT4.4.2) Monoclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:12362
• Gene
  TSC1
• Long gene name
  TSC complex subunit 1
• Synonyms gene
  • TSC
• Synonyms gene name
  • tuberous sclerosis 1
• Synonyms
  • KIAA0243
  • LAM
  • hamartin
• Synonyms name
  • hamartin
• GenBank acession
  • AF013168
• Locus
  9q34
• Discovery year
  1986-01-01
• Pubmed identfication
  • 9242607
  • 10806479
• Classification
  • TSC complex
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000020844
• Locus Specific Databases
  • TSC Mutation Database
  • Global Variome shared LOVD
  • LRG_486

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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