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Target antigen
TrkC
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TrkC(172-186aa QLWQEQGEAKLNSQN), different from the related rat and mouse sequences by three amino acids.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the TrkC Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The TrkC Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
NTRK3(Neurotrophic Tyrosine Kinase Receptor Type 3), also known as TRKC, is a protein that in humans is encoded by the NTRK3 gene. By PCR analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization with the cDNA clone, McGregor et al.(1994) mapped the NTRK3 gene to 15q24-q25. Lamballe et al.(1991) isolated and characterized TRKC, a member of the TRK family of tyrosine protein kinase genes. They found that TRKC is preferentially expressed in the brain; in situ hybridization studies showed transcripts in the hippocampus, cerebral cortex, and the granular cell layer of the cerebellum. By functional studies in HeLa cells, Muinos-Gimeno et al.(2009) demonstrated that 5 miRNAs regulate the truncated form of NTRK3.
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Related articles
1. Lamballe, F., Klein, R., Barbacid, M. TRKC, a new member of the TRK family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66: 967-979, 1991. 2. McGregor, L. M., Baylin, S. B., Griffin, C. A., Hawkins, A. L., Nelkin, B. D. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. Genomics 22: 267-272, 1994. 3. Muinos-Gimeno, M., Guidi, M., Kagerbauer, B., Martin-Santos, R., Navines, R., Alonso, P., Menchon, J. M., Gratacos, M., Estivill, X., Espinosa-Parrilla, Y. Allele variants in functional microRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. Hum. Mutat. 30: 1062-1071, 2009.
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Gene Name
NTRK3
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Protein Name
NT-3 growth factor receptor
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Gene Full Name
neurotrophic tyrosine kinase, receptor, type 3
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Synonyms
EC 2.7.10.1 antibody|ETS related protein neurotrophic receptor tyrosine kinase fusion antibody|ETV6 NTRK3 fusion antibody|GP145 TrkC antibody|gp145(trkC) antibody|GP145-TrkC antibody|GP145TrkC antibody|Neurotrophic tyrosine kinase receptor type 3 antibody|Neurotrophin 3 receptor antibody|NT 3 growth factor receptor antibody|NT 3 growth factor receptor precursor antibody|NT 3 receptor antibody|NT-3 growth factor receptor antibody|Ntrk3 antibody|NTRK3_HUMAN antibody|OTTHUMP00000192915 antibody|TRK C antibody|Trk-C antibody|TrkC tyrosine kinase antibody|Tyrosine kinase receptor C antibody
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Uniprot ID
Q16288
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
