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Products_type
Antibody
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Products_short_name
[CD71 / Transferrin Receptor (TFRC)]
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Products_name_syn
[Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR]
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Other_names
[transferrin receptor protein 1 isoform 1; Transferrin receptor protein 1; transferrin receptor protein 1; transferrin receptor; T9; p90; CD_antigen: CD71]
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Products_gene_name
[TFRC]
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Other_gene_names
[TFRC; TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46; TR; TfR; TfR1; Trfr; sTfR]
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Clonality
Monoclonal
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Clone
[TFRC/1149]
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Reactivity
Human
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Specificity
It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
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Form
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stability
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_application
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
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Properties
If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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French translation
anticorps
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Gene target
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Gene symbol
TFRC
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Short name
CD71 / Transferrin Receptor (TFRC) Mouse Monoclonal Antibody
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Technique
Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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Host
Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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Isotype
IgG1, kappa
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Species
Mouse, Mouses
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Alternative name
CD71 / Transferrin Receptor (transferrin receptor (p90, CD71)) Mouse monoclonal (antibody to-)
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Alternative technique
antibodies, murine
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Alternative to gene target
transferrin receptor (p90, CD71), CD71 and p90 and T9 and TFR and TFR1 and TR and TRFR, TFRC and IDBG-71016 and ENSG00000072274 and 102724492,7037, poly(A) RNA binding, Extracellular, Tfrc and IDBG-154429 and ENSMUSG00000022797 and 22042, TFRC and IDBG-633841 and ENSBTAG00000032719 and 100852305,504698
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