TRAIL (TNF-Related Apoptosis-Inducing Ligand), APO-2L, 281aa cytotoxic prot, Clone: 27B12, Mouse Monoclonal antibody-Human; paraffin, IH/WB
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Catalog numberMEDCLA845
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PricePlease ask
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Size1000ul
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Alternative name 1TRAIL (TNF-Related Apoptosis-Inducing Ligand), APO-2L, 281aa cytotoxic prot, Clone: 27B12, Mab anti-Human; paraffin, IH/WB
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Alternative name 2TRAIL (TNF-Related Apoptosis-Inducing Ligand), APO-2L, 281aa cytotoxic prot, Clone: 27B12, Mab antibody-Human; paraffin, IH/WB
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Alternative name 3TRAIL (TNF-Related Apoptosis-Inducing Ligand), APO-2L, 281aa cytotoxic prot, Clone: 27B12, Mab antibody-Homo sapiens; paraffin, IH/WB
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Alternative name 4anti-TRAIL TNF-Related Apoptosis-Inducing Ligand APO-2L 281aa cytotoxic prot Clone: 27B12
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Alternative name 5TRAIL TNF-Related Apoptosis-Inducing Ligand APO-2L 281aa cytotoxic prot Clone: 27B12
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ClonalityMonoclonal Antibody
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DescriptionThis is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against. If used correctly and according the protocol, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications. Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches; in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required.
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Storage and handlingGenerally, antibodies that are lyophilized can be transported at ambient temperature and stored for short terms at +4 degrees Celsius, for longer periods - at -20 . Antibodies in a liquid form can be shipped and stored for a short period of time at +4 degrees Celsius, for long term storage (up to one year) 25-50% glycerol or ethylene glycol should be added and then the container has to be stored at -20°C.
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AdvisoryTo keep the quality and the affinity of the antibody cycles of freezing and thawing should be avoided. For antibodies in a liquid form or reconstituted lyophilized antibodies small amounts of the soultion could be captured on the cap or the walls of the container. Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom.
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PropertiesIf you buy Antibodies supplied by accurate-monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional descriptionThis 1 is suited for programmed cell-death studies. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
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AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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GeneTumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.
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French translationanticorps
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Gene target
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Gene symbolTNFSF10, TNF, TNFRSF1A, TNFRSF1B, LTBR, FAS, AOPEP, TNFRSF10B, TNFRSF25
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Short nameTRAIL (TNF- Apoptosis- Ligand), APO-2L, 281aa cytotoxic prot, Clone: 27B12, Mouse Monoclonal antibody- ; paraffin, IH/
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TechniqueMouse monoclonal, apoptosis, Antibody, paraffin, Mouse, WB, antibodies against human proteins, antibodies for, apoptosis pathway, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals, Western Blot on a membrane
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Hostmouse monoclonal, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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SpeciesHuman, Humans, Mouses
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Alternative nameTRAIL (tumor necrosis factor-Related programmed cellular destruction-Inducing Ligand), APO-2L, 281aa cytotoxic prot, clonality: 27B12, Mouse monoclonal (antibody to-)-H. sapiens; paraffin, IH/Western Blot
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Alternative techniquecelldeath, antibodies, murine
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Alternative to gene targettumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943
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Gene info
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Identity
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Gene
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Long gene nameTNF superfamily member 10
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Synonyms gene name
- tumor necrosis factor (ligand) superfamily, member 10
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-12-04
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Pubmed identfication
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Classification
- CD molecules
- Tumor necrosis factor superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametumor necrosis factor
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor (TNF superfamily, member 2)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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Classification
- Tumor necrosis factor superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTNF receptor superfamily member 1A
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1A
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-01-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameTNF receptor superfamily member 1B
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1B
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-01-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- MicroRNA protein coding host genes
- Tumor necrosis factor receptor superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namelymphotoxin beta receptor
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1996-03-12
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Entrez gene record
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Pubmed identfication
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Classification
- Tumor necrosis factor receptor superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameFas cell surface death receptor
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 6
- Fas (TNF receptor superfamily, member 6)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-06-25
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Entrez gene record
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Pubmed identfication
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Classification
- Tumor necrosis factor receptor superfamily
- Death inducing signaling complex
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameaminopeptidase O (putative)
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Synonyms gene
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Synonyms gene name
- chromosome 9 open reading frame 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-01-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M1 metallopeptidases
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTNF receptor superfamily member 10b
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 10b
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-12-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTNF receptor superfamily member 25
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
- tumor necrosis factor receptor superfamily, member 25
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-12-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tumor necrosis factor receptor superfamily
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.
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Tree numbers
- E01.370.225.500.620.720.610
- E01.370.225.750.600.720.610
- E05.200.500.620.720.610
- E05.200.750.600.720.610
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Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics